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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3223
http://purl.obolibrary.org/obo/dinto_3223
|
|---|---|
| Preferred Name | axin-1 |
| Synonyms |
haxin
axis inhibition protein 1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | axin-1
|
|---|---|
| label | axin-1
|
| Definition | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Wild-type axin 1 can induce apoptosis in hepatocellular and colorectal cancer cells. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7
|
| type | |
| Synonym |
haxin
axis inhibition protein 1
|
| OrganismClass | human
|
| xref |
DrugBank:5676
UniProt ID:O15169
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3223
|
| related with | |
| Gene | axin1
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |