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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3181
http://purl.obolibrary.org/obo/dinto_3181
|
|---|---|
| Preferred Name | tumor necrosis factor receptor superfamily member 1b |
| Synonyms |
tumor necrosis factor receptor 2
etanercept
tnf-r2
cd120b antigen
p80 tnf-alpha receptor
tumor necrosis factor receptor superfamily member 1b precursor
tumor necrosis factor receptor type ii
p75
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | tumor necrosis factor receptor superfamily member 1b
|
|---|---|
| label | tumor necrosis factor receptor superfamily member 1b
|
| Definition | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity
|
| type | |
| Synonym |
tumor necrosis factor receptor 2
etanercept
tnf-r2
cd120b antigen
p80 tnf-alpha receptor
tumor necrosis factor receptor superfamily member 1b precursor
tumor necrosis factor receptor type ii
p75
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|
| OrganismClass | human
|
| xref |
DrugBank:1269
UniProt ID:P20333
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3181
|
| related with | |
| Gene | tnfrsf1b
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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