ec 2.7.13.3

http://purl.obolibrary.org/obo/dinto_2984

http://purl.obolibrary.org/obo/dinto_DB04395

Member of the two-component regulatory system phoQ/phoP involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to phoP, which results in the expression of phoP-activated genes (PAG) and repression of phoP-repressed genes (PRG). In presence of high periplasmic Mg(2+) concentrations, acts as a protein phosphatase that dephosphorylates phospho-phoP, which results in the repression of phoP-activated genes and may lead to expression of some phoP- repressed genes (By similarity). Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two- component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes

DrugBank Database

phoq

sensor protein phoq

bacterial

obo2:dinto_2984

sensor protein phoq

http://purl.obolibrary.org/obo/dinto_DB04395

ec 2.7.13.3

UniProt ID:P23837

DrugBank:5644

http://purl.obolibrary.org/obo/dinto_000128