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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2962
http://purl.obolibrary.org/obo/dinto_2962
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|---|---|
| Preferred Name | voltage-dependent l-type calcium channel subunit alpha-1s |
| Synonyms |
calcium channel, l type, alpha-1 polypeptide, isoform 3, skeletal muscle
voltage- gated calcium channel subunit alpha cav1.1
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | voltage-dependent l-type calcium channel subunit alpha-1s
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|---|---|
| label | voltage-dependent l-type calcium channel subunit alpha-1s
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| Definition | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the "high-voltage activated" (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle
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| Synonym | calcium channel, l type, alpha-1 polypeptide, isoform 3, skeletal muscle
voltage- gated calcium channel subunit alpha cav1.1
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| OrganismClass | human
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| xref |
DrugBank:4111
UniProt ID:Q13698
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_2962
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| Gene | cacna1s
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