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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2917
http://purl.obolibrary.org/obo/dinto_2917
|
|---|---|
| Preferred Name | tyrosine-protein kinase syk |
| Synonyms |
ec 2.7.10.2
spleen tyrosine kinase
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | tyrosine-protein kinase syk
|
|---|---|
| label | tyrosine-protein kinase syk
|
| Definition | Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion
|
| type | |
| is inhibited by | |
| Synonym |
ec 2.7.10.2
spleen tyrosine kinase
|
| OrganismClass | human
|
| xref |
DrugBank:2408
UniProt ID:P43405
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_2917
|
| related with | |
| Gene | syk
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |