The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	glucocorticoid receptor
Synonyms	gr
ID	http://purl.obolibrary.org/obo/dinto_2874
binds	http://purl.obolibrary.org/obo/dinto_DB02210
Definition	Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth
definition source	DrugBank Database
Gene	nr3c1
is activated by	http://purl.obolibrary.org/obo/dinto_DB00896 http://purl.obolibrary.org/obo/CHEBI_5106 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_50848 http://purl.obolibrary.org/obo/CHEBI_31620 http://purl.obolibrary.org/obo/dinto_DB00253 http://purl.obolibrary.org/obo/dinto_DB01130 http://purl.obolibrary.org/obo/CHEBI_31441 http://purl.obolibrary.org/obo/CHEBI_74899 http://purl.obolibrary.org/obo/dinto_DB01384 http://purl.obolibrary.org/obo/CHEBI_59750 http://purl.obolibrary.org/obo/CHEBI_6970 http://purl.obolibrary.org/obo/CHEBI_9667 http://purl.obolibrary.org/obo/CHEBI_691037 http://purl.obolibrary.org/obo/CHEBI_3002 http://purl.obolibrary.org/obo/dinto_DB01380 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/dinto_DB00591 http://purl.obolibrary.org/obo/dinto_DB01410 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/dinto_DB00324 http://purl.obolibrary.org/obo/CHEBI_53776 http://purl.obolibrary.org/obo/CHEBI_205919 http://purl.obolibrary.org/obo/dinto_DB06781 http://purl.obolibrary.org/obo/CHEBI_6722 http://purl.obolibrary.org/obo/CHEBI_50885 http://purl.obolibrary.org/obo/dinto_DB00846 http://purl.obolibrary.org/obo/CHEBI_59582 http://purl.obolibrary.org/obo/CHEBI_204734 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/dinto_DB00596 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_31199 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/dinto_DB01047 http://purl.obolibrary.org/obo/CHEBI_50851
is binded by	http://purl.obolibrary.org/obo/dinto_DB00896 http://purl.obolibrary.org/obo/CHEBI_5106 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_50848 http://purl.obolibrary.org/obo/CHEBI_31620 http://purl.obolibrary.org/obo/dinto_DB00253 http://purl.obolibrary.org/obo/dinto_DB01130 http://purl.obolibrary.org/obo/CHEBI_31441 http://purl.obolibrary.org/obo/CHEBI_74899 http://purl.obolibrary.org/obo/dinto_DB01384 http://purl.obolibrary.org/obo/CHEBI_59750 http://purl.obolibrary.org/obo/CHEBI_6970 http://purl.obolibrary.org/obo/CHEBI_9667 http://purl.obolibrary.org/obo/CHEBI_691037 http://purl.obolibrary.org/obo/CHEBI_50692 http://purl.obolibrary.org/obo/CHEBI_3002 http://purl.obolibrary.org/obo/CHEBI_3207 http://purl.obolibrary.org/obo/dinto_DB01380 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/dinto_DB00591 http://purl.obolibrary.org/obo/dinto_DB01410 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/dinto_DB00324 http://purl.obolibrary.org/obo/CHEBI_53776 http://purl.obolibrary.org/obo/CHEBI_205919 http://purl.obolibrary.org/obo/dinto_DB06781 http://purl.obolibrary.org/obo/dinto_DB00846 http://purl.obolibrary.org/obo/CHEBI_59582 http://purl.obolibrary.org/obo/CHEBI_204734 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/dinto_DB00596 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_31199 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/dinto_DB01047 http://purl.obolibrary.org/obo/CHEBI_50851 http://purl.obolibrary.org/obo/CHEBI_5120 http://purl.obolibrary.org/obo/CHEBI_6722 http://purl.obolibrary.org/obo/CHEBI_50885
is blocked by	http://purl.obolibrary.org/obo/CHEBI_50692 http://purl.obolibrary.org/obo/CHEBI_3207 http://purl.obolibrary.org/obo/CHEBI_5120
is modulated by	http://purl.obolibrary.org/obo/CHEBI_50692 http://purl.obolibrary.org/obo/CHEBI_3207 http://purl.obolibrary.org/obo/CHEBI_5120 http://purl.obolibrary.org/obo/dinto_DB00896 http://purl.obolibrary.org/obo/CHEBI_5106 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_50848 http://purl.obolibrary.org/obo/CHEBI_31620 http://purl.obolibrary.org/obo/dinto_DB00253 http://purl.obolibrary.org/obo/dinto_DB01130 http://purl.obolibrary.org/obo/CHEBI_31441 http://purl.obolibrary.org/obo/CHEBI_74899 http://purl.obolibrary.org/obo/dinto_DB01384 http://purl.obolibrary.org/obo/CHEBI_59750 http://purl.obolibrary.org/obo/CHEBI_6970 http://purl.obolibrary.org/obo/CHEBI_9667 http://purl.obolibrary.org/obo/CHEBI_691037 http://purl.obolibrary.org/obo/CHEBI_3002 http://purl.obolibrary.org/obo/dinto_DB01380 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/dinto_DB00591 http://purl.obolibrary.org/obo/dinto_DB01410 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/dinto_DB00324 http://purl.obolibrary.org/obo/CHEBI_53776 http://purl.obolibrary.org/obo/CHEBI_205919 http://purl.obolibrary.org/obo/dinto_DB06781 http://purl.obolibrary.org/obo/CHEBI_6722 http://purl.obolibrary.org/obo/CHEBI_50885 http://purl.obolibrary.org/obo/dinto_DB00846 http://purl.obolibrary.org/obo/CHEBI_59582 http://purl.obolibrary.org/obo/CHEBI_204734 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/dinto_DB00596 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_31199 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/dinto_DB01047 http://purl.obolibrary.org/obo/CHEBI_50851
is pharmacological target of	http://purl.obolibrary.org/obo/dinto_DB00896 http://purl.obolibrary.org/obo/CHEBI_5106 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_50848 http://purl.obolibrary.org/obo/CHEBI_31620 http://purl.obolibrary.org/obo/dinto_DB00253 http://purl.obolibrary.org/obo/dinto_DB01130 http://purl.obolibrary.org/obo/CHEBI_31441 http://purl.obolibrary.org/obo/CHEBI_74899 http://purl.obolibrary.org/obo/dinto_DB01384 http://purl.obolibrary.org/obo/CHEBI_59750 http://purl.obolibrary.org/obo/CHEBI_6970 http://purl.obolibrary.org/obo/CHEBI_9667 http://purl.obolibrary.org/obo/CHEBI_691037 http://purl.obolibrary.org/obo/CHEBI_50692 http://purl.obolibrary.org/obo/CHEBI_3002 http://purl.obolibrary.org/obo/CHEBI_3207 http://purl.obolibrary.org/obo/dinto_DB01380 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/dinto_DB00591 http://purl.obolibrary.org/obo/dinto_DB01410 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/dinto_DB00324 http://purl.obolibrary.org/obo/CHEBI_53776 http://purl.obolibrary.org/obo/CHEBI_205919 http://purl.obolibrary.org/obo/dinto_DB06781 http://purl.obolibrary.org/obo/dinto_DB00846 http://purl.obolibrary.org/obo/CHEBI_59582 http://purl.obolibrary.org/obo/CHEBI_204734 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/dinto_DB00596 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_31199 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/dinto_DB01047 http://purl.obolibrary.org/obo/CHEBI_50851
label	glucocorticoid receptor
OrganismClass	human
prefixIRI	obo2:dinto_2874
prefLabel	glucocorticoid receptor
related with	http://purl.obolibrary.org/obo/dinto_DB02210
Synonym	gr
xref	UniProt ID:P04150 DrugBank:871
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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Mapping To	Ontology	Source
http://sbmi.uth.tmc.edu/ontology/ochv#C0034809	OCHV	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/3648007	SNOMEDCT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17071	NCIT	LOOM
http://www.drugtargetontology.org/dto/DTO_00117517	DTO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10612	OCHV	LOOM
http://purl.uniprot.org/uniprot/P04150	FTC	LOOM
http://purl.obolibrary.org/obo/PR_000011406	PR	LOOM
http://purl.obolibrary.org/obo/PR_000011406	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000011406	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/PR_000011406	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000011406	NIFSTD	LOOM
http://purl.obolibrary.org/obo/NCIT_C17071	BERO	LOOM
http://purl.jp/bio/4/id/200906053932751340	IOBC	LOOM