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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2830
http://purl.obolibrary.org/obo/dinto_2830
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|---|---|
| Preferred Name | estrogen receptor beta |
| Synonyms |
er-beta
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | estrogen receptor beta
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|---|---|
| label | estrogen receptor beta
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| Definition | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
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| type | |
| is activated by |
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| Synonym | er-beta
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| OrganismClass | human
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| xref |
DrugBank:869
UniProt ID:Q92731
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_2830
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| related with |
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| is pharmacological target of | |
| is blocked by | |
| Gene | esr2
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| subClassOf |
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| No notes to display |