The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	vascular endothelial growth factor a
Synonyms	vascular permeability factor vascular endothelial growth factor a precursor vpf vegf-a
ID	http://purl.obolibrary.org/obo/dinto_2763
binds	http://purl.obolibrary.org/obo/dinto_DB00112 http://purl.obolibrary.org/obo/dinto_DB03088 http://purl.obolibrary.org/obo/CHEBI_3441 http://purl.obolibrary.org/obo/dinto_DB01270 http://purl.obolibrary.org/obo/dinto_DB03754 http://purl.obolibrary.org/obo/CHEBI_31654
Definition	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145
definition source	DrugBank Database
Gene	vegfa
is binded by	http://purl.obolibrary.org/obo/dinto_DB08885 http://purl.obolibrary.org/obo/dinto_DB00112 http://purl.obolibrary.org/obo/dinto_DB06779 http://purl.obolibrary.org/obo/dinto_DB01270 http://purl.obolibrary.org/obo/CHEBI_49960 http://purl.obolibrary.org/obo/CHEBI_50694
is inhibited by	http://purl.obolibrary.org/obo/CHEBI_49960 http://purl.obolibrary.org/obo/dinto_DB06779 http://purl.obolibrary.org/obo/CHEBI_50694
is pharmacological target of	http://purl.obolibrary.org/obo/dinto_DB00112 http://purl.obolibrary.org/obo/dinto_DB06779 http://purl.obolibrary.org/obo/dinto_DB08885 http://purl.obolibrary.org/obo/dinto_DB01270
label	vascular endothelial growth factor a
OrganismClass	human
prefixIRI	obo2:dinto_2763
prefLabel	vascular endothelial growth factor a
related with	http://purl.obolibrary.org/obo/dinto_DB00112 http://purl.obolibrary.org/obo/dinto_DB03088 http://purl.obolibrary.org/obo/CHEBI_3441 http://purl.obolibrary.org/obo/dinto_DB01270 http://purl.obolibrary.org/obo/dinto_DB03754 http://purl.obolibrary.org/obo/CHEBI_31654
Synonym	vascular permeability factor vascular endothelial growth factor a precursor vpf vegf-a
xref	UniProt ID:P15692 DrugBank:183
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/LNC/MTHU048267	LOINC	LOOM
http://www.ncbi.nlm.nih.gov/gene/22339	NIFSTD	LOOM
http://purl.bioontology.org/ontology/LNC/LP185747-5	LOINC	LOOM
http://purl.obolibrary.org/obo/NCIT_C20450	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0023145	OMIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021640	PMAPP-PMO	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6348191c_5c8a_4250_b394_655e59be6b09	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6348191c_5c8a_4250_b394_655e59be6b09	CVAO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D042461	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D042461	BERO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20450	NCIT	LOOM
http://purl.jp/bio/4/id/200906081728976914	IOBC	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571347974240596174	ACVD_ONTOLOGY	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.529.100.800.200	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.467.100.800.200	RH-MESH	LOOM
http://purl.obolibrary.org/obo/PR_000017284	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000017284	NIFSTD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.276.100.800.200	RH-MESH	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01476	MIO	LOOM
http://purl.uniprot.org/uniprot/P15692	FTC	LOOM
http://purl.bioontology.org/ontology/OMIM/192240	OMIM	LOOM
http://scai.fraunhofer.de/CSEO#CSEO_00001109	CSEO	LOOM
http://purl.bioontology.org/ontology/MESH/D042461	MESH	LOOM
http://doe-generated-ontology.com/OntoAD#C0078058	ONTOAD	LOOM