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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2651
http://purl.obolibrary.org/obo/dinto_2651
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|---|---|
| Preferred Name | cytochrome p450 1a2 |
| Synonyms |
p(3)450
p450 4
p450-p3
cypia2
ec 1.14.14.1
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cytochrome p450 1a2
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|---|---|
| label | cytochrome p450 1a2
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| is induced by |
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| metabolizes |
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| Definition | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen
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| type | |
| is inhibited by |
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| Synonym |
p(3)450
p450 4
p450-p3
cypia2
ec 1.14.14.1
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| OrganismClass | human
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| xref |
UniProt ID:P05177
DrugBank:4200
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_2651
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| related with | |
| Gene | cyp1a2
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| subClassOf |
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| No notes to display |