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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2461
http://purl.obolibrary.org/obo/dinto_2461
|
|---|---|
| Preferred Name | protein disulfide-isomerase |
| Synonyms |
cellular thyroid hormone-binding protein
protein disulfide-isomerase precursor
prolyl 4- hydroxylase subunit beta
pdi
ec 5.3.4.1
p55
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | protein disulfide-isomerase
|
|---|---|
| label | protein disulfide-isomerase
|
| Definition | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP
|
| type | |
| Synonym |
cellular thyroid hormone-binding protein
protein disulfide-isomerase precursor
prolyl 4- hydroxylase subunit beta
pdi
ec 5.3.4.1
p55
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|
| OrganismClass | human
|
| xref |
DrugBank:4240
UniProt ID:P07237
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_2461
|
| related with | |
| Gene | p4hb
|
| subClassOf |
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