loading...| Preferred Name |
steroidogenic factor 1 |
|
| Synonyms |
stf-1 |
|
| ID |
http://purl.obolibrary.org/obo/dinto_2432 |
|
| Definition |
Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO- NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3 |
|
| definition source |
DrugBank Database |
|
| Gene |
nr5a1 |
|
| label |
steroidogenic factor 1 |
|
| OrganismClass |
human |
|
| prefixIRI |
obo2:dinto_2432 |
|
| prefLabel |
steroidogenic factor 1 |
|
| related with | ||
| Synonym |
stf-1 fushi tarazu factor homolog 1 adrenal 4-binding protein sf-1 steroid hormone receptor ad4bp |
|
| xref |
UniProt ID:Q13285 DrugBank:5760 |
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| subClassOf |