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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2323
http://purl.obolibrary.org/obo/dinto_2323
|
|---|---|
| Preferred Name | map kinase-activated protein kinase 2 |
| Synonyms |
ec 2.7.11.1
mapkapk-2
mk2
mapkap kinase 2
mapk-activated protein kinase 2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | map kinase-activated protein kinase 2
|
|---|---|
| label | map kinase-activated protein kinase 2
|
| Definition | Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity
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| type | |
| Synonym |
ec 2.7.11.1
mapkapk-2
mk2
mapkap kinase 2
mapk-activated protein kinase 2
|
| OrganismClass | human
|
| xref |
DrugBank:2511
UniProt ID:P49137
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_2323
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| related with |
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| Gene | mapkapk2
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| subClassOf |
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