Link to this page
The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2284
http://purl.obolibrary.org/obo/dinto_2284
|
|---|---|
| Preferred Name | hypoxia-inducible factor 1 alpha inhibitor |
| Synonyms |
factor inhibiting hif-1
ec 1.14.11.16
fih-1
hypoxia- inducible factor asparagine hydroxylase
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | hypoxia-inducible factor 1 alpha inhibitor
|
|---|---|
| label | hypoxia-inducible factor 1 alpha inhibitor
|
| Definition | Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases
|
| type | |
| Synonym |
factor inhibiting hif-1
ec 1.14.11.16
fih-1
hypoxia- inducible factor asparagine hydroxylase
|
| OrganismClass | human
|
| xref |
UniProt ID:Q9NWT6
DrugBank:4290
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_2284
|
| related with | |
| Gene | hif1an
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |