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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2017
http://purl.obolibrary.org/obo/dinto_2017
|
|---|---|
| Preferred Name | envelope glycoprotein gp160 |
| Synonyms |
env polyprotein
envelope glycoprotein gp160 precursor
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | envelope glycoprotein gp160
|
|---|---|
| label | envelope glycoprotein gp160
|
| Definition | Allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity)
|
| type | |
| Synonym |
env polyprotein
envelope glycoprotein gp160 precursor
|
| OrganismClass | viral
|
| xref |
DrugBank:4787
UniProt ID:P05884
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_2017
|
| related with | |
| Gene | env
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |