Link to this page
The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_2013
http://purl.obolibrary.org/obo/dinto_2013
|
|---|---|
| Preferred Name | integrin beta-3 |
| Synonyms |
integrin beta-3 precursor
gpiiia
cd61 antigen
platelet membrane glycoprotein iiia
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | integrin beta-3
|
|---|---|
| label | integrin beta-3
|
| Definition | Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
|
| type | |
| Synonym |
integrin beta-3 precursor
gpiiia
cd61 antigen
platelet membrane glycoprotein iiia
|
| OrganismClass | human
|
| xref |
UniProt ID:P05106
DrugBank:2039
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_2013
|
| related with | |
| is pharmacological target of | |
| is blocked by | |
| Gene | itgb3
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |