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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1983
http://purl.obolibrary.org/obo/dinto_1983
|
|---|---|
| Preferred Name | mitogen-activated protein kinase 14 |
| Synonyms |
csbp
ec 2.7.11.24
map kinase p38 alpha
cytokine suppressive anti-inflammatory drug-binding protein
csaid-binding protein
max-interacting protein 2
sapk2a
mitogen-activated protein kinase p38 alpha
map kinase mxi2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | mitogen-activated protein kinase 14
|
|---|---|
| label | mitogen-activated protein kinase 14
|
| Definition | Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis
|
| type | |
| Synonym |
csbp
ec 2.7.11.24
map kinase p38 alpha
cytokine suppressive anti-inflammatory drug-binding protein
csaid-binding protein
max-interacting protein 2
sapk2a
mitogen-activated protein kinase p38 alpha
map kinase mxi2
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|
| OrganismClass | human
|
| xref |
DrugBank:1540
UniProt ID:Q16539
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1983
|
| related with |
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|
| Gene | mapk14
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |