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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1979
http://purl.obolibrary.org/obo/dinto_1979
|
|---|---|
| Preferred Name | solute carrier family 22 member 2 |
| Synonyms |
organic cation transporter 2
hoct2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | solute carrier family 22 member 2
|
|---|---|
| label | solute carrier family 22 member 2
|
| Definition | Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity
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| type | |
| transports |
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| is inhibited by |
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| Synonym |
organic cation transporter 2
hoct2
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| OrganismClass | human
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| xref |
UniProt ID:O15244
DrugBank:6144
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_1979
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| related with | |
| Gene | slc22a2
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |