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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1958
http://purl.obolibrary.org/obo/dinto_1958
|
|---|---|
| Preferred Name | calcium-activated potassium channel subunit beta-1 |
| Synonyms |
bkbeta1
calcium-activated potassium channel subunit beta
hbeta1
calcium-activated potassium channel, subfamily m subunit beta-1
k(vca)beta-1
maxi k channel subunit beta-1
slo-beta
slo-beta-1
bk channel subunit beta-1
charybdotoxin receptor subunit beta-1
bkbeta
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | calcium-activated potassium channel subunit beta-1
|
|---|---|
| label | calcium-activated potassium channel subunit beta-1
|
| Definition | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate
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| type | |
| is inhibited by | |
| Synonym |
bkbeta1
calcium-activated potassium channel subunit beta
hbeta1
calcium-activated potassium channel, subfamily m subunit beta-1
k(vca)beta-1
maxi k channel subunit beta-1
slo-beta
slo-beta-1
bk channel subunit beta-1
charybdotoxin receptor subunit beta-1
bkbeta
See more
See less
|
| OrganismClass | human
|
| xref |
DrugBank:6931
UniProt ID:Q16558
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1958
|
| Gene | kcnmb1
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |