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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1955
http://purl.obolibrary.org/obo/dinto_1955
|
|---|---|
| Preferred Name | calcium-activated potassium channel subunit beta-3 |
| Synonyms |
bk channel subunit beta-3
calcium-activated potassium channel, subfamily m subunit beta-3
charybdotoxin receptor subunit beta-3
k(vca)beta-3
maxi k channel subunit beta-3
bkbeta3
hbeta3
slo-beta-3
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | calcium-activated potassium channel subunit beta-3
|
|---|---|
| label | calcium-activated potassium channel subunit beta-3
|
| Definition | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer
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| type | |
| is inhibited by | |
| Synonym |
bk channel subunit beta-3
calcium-activated potassium channel, subfamily m subunit beta-3
charybdotoxin receptor subunit beta-3
k(vca)beta-3
maxi k channel subunit beta-3
bkbeta3
hbeta3
slo-beta-3
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|
| OrganismClass | human
|
| xref |
DrugBank:6932
UniProt ID:Q9NPA1
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1955
|
| Gene | kcnmb3
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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