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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1954
http://purl.obolibrary.org/obo/dinto_1954
|
|---|---|
| Preferred Name | ribonucleoside-diphosphate reductase subunit m2 b |
| Synonyms |
p53r2
tp53-inducible ribonucleotide reductase m2 b
p53-inducible ribonucleotide reductase small subunit 2-like protein
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | ribonucleoside-diphosphate reductase subunit m2 b
|
|---|---|
| label | ribonucleoside-diphosphate reductase subunit m2 b
|
| Definition | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage
|
| type | |
| is inhibited by | |
| Synonym |
p53r2
tp53-inducible ribonucleotide reductase m2 b
p53-inducible ribonucleotide reductase small subunit 2-like protein
|
| OrganismClass | human
|
| xref |
DrugBank:6108
UniProt ID:Q7LG56
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1954
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| is pharmacological target of | |
| Gene | rrm2b
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| subClassOf |
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| No notes to display |