The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_1858 http://purl.obolibrary.org/obo/dinto_1858
Preferred Name	caspase-3
Synonyms	cpp-32 cysteine protease cpp32 casp-3 apopain yama protein sca-1 ec 3.4.22.56 srebp cleavage activity 1 caspase-3 precursor
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	caspase-3
label	caspase-3
Definition	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin
type	http://www.w3.org/2002/07/owl#Class
Synonym	cpp-32 cysteine protease cpp32 casp-3 apopain yama protein sca-1 ec 3.4.22.56 srebp cleavage activity 1 caspase-3 precursor See more See less
OrganismClass	human
xref	DrugBank:2077 UniProt ID:P42574
definition source	DrugBank Database
prefixIRI	obo2:dinto_1858
related with	http://purl.obolibrary.org/obo/dinto_DB08498 http://purl.obolibrary.org/obo/dinto_DB08213 http://purl.obolibrary.org/obo/dinto_DB08229 http://purl.obolibrary.org/obo/dinto_DB03124 http://purl.obolibrary.org/obo/dinto_DB07696 http://purl.obolibrary.org/obo/dinto_DB06862 http://purl.obolibrary.org/obo/dinto_DB08497 http://purl.obolibrary.org/obo/dinto_DB08251 http://purl.obolibrary.org/obo/CHEBI_50694 http://purl.obolibrary.org/obo/dinto_DB08499 See more See less
Gene	casp3
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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