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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1696
http://purl.obolibrary.org/obo/dinto_1696
|
|---|---|
| Preferred Name | microtubule-associated protein tau |
| Synonyms |
phf-tau
paired helical filament-tau
neurofibrillary tangle protein
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | microtubule-associated protein tau
|
|---|---|
| label | microtubule-associated protein tau
|
| Definition | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization
|
| type | |
| Synonym |
phf-tau
paired helical filament-tau
neurofibrillary tangle protein
|
| OrganismClass | human
|
| xref |
DrugBank:5923
UniProt ID:P10636
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1696
|
| related with | |
| is pharmacological target of | |
| Gene | mapt
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |