loading...| Preferred Name |
voltage-dependent p/q-type calcium channel subunit alpha-1a |
|
| Synonyms |
bi voltage- gated calcium channel subunit alpha cav2.1 brain calcium channel i calcium channel, l type, alpha-1 polypeptide isoform 4 |
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| ID |
http://purl.obolibrary.org/obo/dinto_1540 |
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| Definition |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the "high-voltage activated" (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA) |
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| definition source |
DrugBank Database |
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| Gene |
cacna1a |
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| is binded by |
http://purl.obolibrary.org/obo/CHEBI_64356 http://purl.obolibrary.org/obo/CHEBI_3061 |
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| is inhibited by |
http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_64356 |
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| is pharmacological target of | ||
| label |
voltage-dependent p/q-type calcium channel subunit alpha-1a |
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| OrganismClass |
human |
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| prefixIRI |
obo2:dinto_1540 |
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| prefLabel |
voltage-dependent p/q-type calcium channel subunit alpha-1a |
|
| Synonym |
bi voltage- gated calcium channel subunit alpha cav2.1 brain calcium channel i calcium channel, l type, alpha-1 polypeptide isoform 4 |
|
| xref |
DrugBank:392 UniProt ID:O00555 |
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| subClassOf |