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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1540
http://purl.obolibrary.org/obo/dinto_1540
|
|---|---|
| Preferred Name | voltage-dependent p/q-type calcium channel subunit alpha-1a |
| Synonyms |
bi
voltage- gated calcium channel subunit alpha cav2.1
brain calcium channel i
calcium channel, l type, alpha-1 polypeptide isoform 4
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | voltage-dependent p/q-type calcium channel subunit alpha-1a
|
|---|---|
| label | voltage-dependent p/q-type calcium channel subunit alpha-1a
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| Definition | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the "high-voltage activated" (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)
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| type | |
| is inhibited by | |
| Synonym |
bi
voltage- gated calcium channel subunit alpha cav2.1
brain calcium channel i
calcium channel, l type, alpha-1 polypeptide isoform 4
|
| OrganismClass | human
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| xref |
DrugBank:392
UniProt ID:O00555
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_1540
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| is pharmacological target of | |
| Gene | cacna1a
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| subClassOf |
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| No notes to display |