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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1474
http://purl.obolibrary.org/obo/dinto_1474
|
|---|---|
| Preferred Name | serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform |
| Synonyms |
replication protein c
pp2a-alpha
rp-c
ec 3.1.3.16
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform
|
|---|---|
| label | serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform
|
| Definition | PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen
|
| type | |
| Synonym |
replication protein c
pp2a-alpha
rp-c
ec 3.1.3.16
|
| OrganismClass | human
|
| xref |
DrugBank:4078
UniProt ID:P67775
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1474
|
| related with | |
| Gene | ppp2ca
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |