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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1459
http://purl.obolibrary.org/obo/dinto_1459
|
|---|---|
| Preferred Name | gamma-aminobutyric acid type b receptor, subunit 2 |
| Synonyms |
gamma-aminobutyric acid type b receptor, subunit 2 precursor
gb2
g-protein coupled receptor 51
hg20
gaba-b-r2
gaba-b receptor 2
gababr2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | gamma-aminobutyric acid type b receptor, subunit 2
|
|---|---|
| label | gamma-aminobutyric acid type b receptor, subunit 2
|
| Definition | Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception
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| type | |
| is activated by | |
| Synonym |
gamma-aminobutyric acid type b receptor, subunit 2 precursor
gb2
g-protein coupled receptor 51
hg20
gaba-b-r2
gaba-b receptor 2
gababr2
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|
| OrganismClass | human
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| xref |
UniProt ID:O75899
DrugBank:4094
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_1459
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| is pharmacological target of | |
| Gene | gabbr2
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| subClassOf |
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