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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1454
http://purl.obolibrary.org/obo/dinto_1454
|
|---|---|
| Preferred Name | neuronal acetylcholine receptor subunit alpha-9 |
| Synonyms |
neuronal acetylcholine receptor subunit alpha-9 precursor
nachr alpha 9
nicotinic acetylcholine receptor subunit alpha 9
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | neuronal acetylcholine receptor subunit alpha-9
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|---|---|
| label | neuronal acetylcholine receptor subunit alpha-9
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| Definition | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion
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| type | |
| is activated by | |
| is inhibited by | |
| Synonym |
neuronal acetylcholine receptor subunit alpha-9 precursor
nachr alpha 9
nicotinic acetylcholine receptor subunit alpha 9
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| OrganismClass | human
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| xref |
DrugBank:4097
UniProt ID:Q9UGM1
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_1454
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| related with | |
| Gene | chrna9
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| subClassOf |
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