The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_1446 http://purl.obolibrary.org/obo/dinto_1446
Preferred Name	aryl hydrocarbon receptor
Synonyms	bhlhe76 ah receptor class e basic helix-loop-helix protein 76 ahr
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	aryl hydrocarbon receptor
label	aryl hydrocarbon receptor
Definition	Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues
type	http://www.w3.org/2002/07/owl#Class
is activated by	http://purl.obolibrary.org/obo/CHEBI_6916 http://purl.obolibrary.org/obo/CHEBI_5132 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/dinto_DB01404 http://purl.obolibrary.org/obo/CHEBI_7575 http://purl.obolibrary.org/obo/CHEBI_6402 See more See less
Synonym	bhlhe76 ah receptor class e basic helix-loop-helix protein 76 ahr
OrganismClass	human
xref	DrugBank:6220 UniProt ID:P35869
definition source	DrugBank Database
prefixIRI	obo2:dinto_1446
Gene	ahr
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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