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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1314
http://purl.obolibrary.org/obo/dinto_1314
|
|---|---|
| Preferred Name | trace amine-associated receptor 1 |
| Synonyms |
tar-1
trace amine receptor 1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | trace amine-associated receptor 1
|
|---|---|
| label | trace amine-associated receptor 1
|
| Definition | Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase
|
| type | |
| is activated by | |
| Synonym |
tar-1
trace amine receptor 1
|
| OrganismClass | human
|
| xref |
UniProt ID:Q96RJ0
DrugBank:1636
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1314
|
| is pharmacological target of | |
| Gene | taar1
|
| subClassOf |
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| No notes to display |