loading...| Preferred Name |
high affinity nerve growth factor receptor |
|
| Synonyms |
neurotrophic tyrosine kinase receptor type 1 trk-a high affinity nerve growth factor receptor precursor trk1 transforming tyrosine kinase protein ec 2.7.10.1 p140-trka |
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| ID |
http://purl.obolibrary.org/obo/dinto_1246 |
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| Definition |
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway |
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| definition source |
DrugBank Database |
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| Gene |
ntrk1 |
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| is activated by | ||
| is binded by |
http://purl.obolibrary.org/obo/CHEBI_68647 |
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| is blocked by | ||
| is inhibited by | ||
| is modulated by | ||
| is pharmacological target of | ||
| label |
high affinity nerve growth factor receptor |
|
| OrganismClass |
human |
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| prefixIRI |
obo2:dinto_1246 |
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| prefLabel |
high affinity nerve growth factor receptor |
|
| Synonym |
neurotrophic tyrosine kinase receptor type 1 trk-a high affinity nerve growth factor receptor precursor trk1 transforming tyrosine kinase protein ec 2.7.10.1 p140-trka |
|
| xref |
DrugBank:1618 UniProt ID:P04629 |
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| subClassOf |