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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1246
http://purl.obolibrary.org/obo/dinto_1246
|
|---|---|
| Preferred Name | high affinity nerve growth factor receptor |
| Synonyms |
neurotrophic tyrosine kinase receptor type 1
trk-a
high affinity nerve growth factor receptor precursor
trk1 transforming tyrosine kinase protein
ec 2.7.10.1
p140-trka
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | high affinity nerve growth factor receptor
|
|---|---|
| label | high affinity nerve growth factor receptor
|
| Definition | Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway
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| type | |
| is activated by | |
| is inhibited by | |
| Synonym |
neurotrophic tyrosine kinase receptor type 1
trk-a
high affinity nerve growth factor receptor precursor
trk1 transforming tyrosine kinase protein
ec 2.7.10.1
p140-trka
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|
| OrganismClass | human
|
| xref |
DrugBank:1618
UniProt ID:P04629
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_1246
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| is pharmacological target of | |
| is blocked by | |
| Gene | ntrk1
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| subClassOf |
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