The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	mitogen-activated protein kinase 8
Synonyms	c-jun n-terminal kinase 1 jnk-46 stress-activated protein kinase jnk1
ID	http://purl.obolibrary.org/obo/dinto_1237
binds	http://purl.obolibrary.org/obo/dinto_DB01782 http://purl.obolibrary.org/obo/dinto_DB07845 http://purl.obolibrary.org/obo/dinto_DB07272 http://purl.obolibrary.org/obo/dinto_DB07268 http://purl.obolibrary.org/obo/dinto_DB07218 http://purl.obolibrary.org/obo/dinto_DB07276
Definition	JNK1 isoforms display different binding patterns:beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms
definition source	DrugBank Database
Gene	mapk8
label	mitogen-activated protein kinase 8
OrganismClass	human
prefixIRI	obo2:dinto_1237
prefLabel	mitogen-activated protein kinase 8
related with	http://purl.obolibrary.org/obo/dinto_DB01782 http://purl.obolibrary.org/obo/dinto_DB07845 http://purl.obolibrary.org/obo/dinto_DB07272 http://purl.obolibrary.org/obo/dinto_DB07268 http://purl.obolibrary.org/obo/dinto_DB07218 http://purl.obolibrary.org/obo/dinto_DB07276
Synonym	c-jun n-terminal kinase 1 jnk-46 stress-activated protein kinase jnk1
xref	UniProt ID:P45983 DrugBank:6292
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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Mapping To	Ontology	Source
http://www.phoc.org.cn/pmo/class/PMO_00020612	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0024004	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.696.620.682.700.646.750.374.500	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D048055	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906094436455055	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.696.620.682.700.567.513.500	RH-MESH	LOOM
http://id.nlm.nih.gov/mesh/D048055	MDM	LOOM
http://purl.bioontology.org/ontology/OMIM/601158	OMIM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.360.450.340.500	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17780	NCIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C17780	BERO	LOOM
http://purl.obolibrary.org/obo/PR_000002206	PR	LOOM
http://purl.obolibrary.org/obo/PR_000002206	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000002206	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000002206	NIFSTD	LOOM
http://purl.bioontology.org/ontology/LNC/LP36223-3	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.476.450.340.500	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D048055	MESH	LOOM
http://www.drugtargetontology.org/dto/DTO_03100320	DTO	LOOM
http://purl.obolibrary.org/obo/MESH_D048055	BERO	LOOM