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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1221
http://purl.obolibrary.org/obo/dinto_1221
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|---|---|
| Preferred Name | cytochrome p450 2c8 |
| Synonyms |
p450 form 1
p450 iic2
cypiic8
s-mephenytoin 4-hydroxylase
p450 mp- 12/mp-20
ec 1.14.14.1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cytochrome p450 2c8
|
|---|---|
| label | cytochrome p450 2c8
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| is induced by |
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| metabolizes |
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| Definition | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol)
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| type | |
| is inhibited by |
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|
| Synonym |
p450 form 1
p450 iic2
cypiic8
s-mephenytoin 4-hydroxylase
p450 mp- 12/mp-20
ec 1.14.14.1
See more
See less
|
| OrganismClass | human
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| xref |
UniProt ID:P10632
DrugBank:4924
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_1221
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| related with | |
| Gene | cyp2c8
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| subClassOf |
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