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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1092
http://purl.obolibrary.org/obo/dinto_1092
|
|---|---|
| Preferred Name | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 |
| Synonyms |
paps synthetase 1
sk 1
sk1
sulfurylase kinase 1
papss 1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1
|
|---|---|
| label | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1
|
| Definition | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS:activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells
|
| type | |
| Synonym |
paps synthetase 1
sk 1
sk1
sulfurylase kinase 1
papss 1
|
| OrganismClass | human
|
| xref |
UniProt ID:O43252
DrugBank:5278
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1092
|
| related with | |
| Gene | papss1
|
| subClassOf |
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