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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_1017
http://purl.obolibrary.org/obo/dinto_1017
|
|---|---|
| Preferred Name | integrin alpha-iib |
| Synonyms |
gpalpha iib
cd41 antigen
integrin alpha-iib precursor
gpiib
platelet membrane glycoprotein iib
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | integrin alpha-iib
|
|---|---|
| label | integrin alpha-iib
|
| Definition | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface
|
| type | |
| Synonym |
gpalpha iib
cd41 antigen
integrin alpha-iib precursor
gpiib
platelet membrane glycoprotein iib
|
| OrganismClass | human
|
| xref |
DrugBank:488
UniProt ID:P08514
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_1017
|
| is pharmacological target of | |
| is blocked by | |
| Gene | itga2b
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |