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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_0901
http://purl.obolibrary.org/obo/dinto_0901
|
|---|---|
| Preferred Name | cytochrome p450 3a4 |
| Synonyms |
nifedipine oxidase
p450-pcn1
quinine 3-monooxygenase
nf-25
ec 1.14.13.67
ec 1.14.13.97
taurochenodeoxycholate 6-alpha- hydroxylase
cypiiia4
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cytochrome p450 3a4
|
|---|---|
| label | cytochrome p450 3a4
|
| is induced by |
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| metabolizes |
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| Definition | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide
|
| type | |
| is inhibited by |
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|
| Synonym |
nifedipine oxidase
p450-pcn1
quinine 3-monooxygenase
nf-25
ec 1.14.13.67
ec 1.14.13.97
taurochenodeoxycholate 6-alpha- hydroxylase
cypiiia4
See more
See less
|
| OrganismClass | human
|
| xref |
UniProt ID:P08684
DrugBank:4512
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_0901
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| related with | |
| Gene | cyp3a4
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |