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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_0883
http://purl.obolibrary.org/obo/dinto_0883
|
|---|---|
| Preferred Name | atp-binding cassette sub-family g member 2 |
| Synonyms |
cd338 antigen
cdw338
breast cancer resistance protein
placenta-specific atp- binding cassette transporter
mitoxantrone resistance-associated protein
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | atp-binding cassette sub-family g member 2
|
|---|---|
| label | atp-binding cassette sub-family g member 2
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| is induced by | |
| Definition | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123
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| type | |
| transports |
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| is inhibited by |
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| Synonym |
cd338 antigen
cdw338
breast cancer resistance protein
placenta-specific atp- binding cassette transporter
mitoxantrone resistance-associated protein
|
| OrganismClass | human
|
| xref |
DrugBank:1732
UniProt ID:Q9UNQ0
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_0883
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| is blocked by | |
| Gene | abcg2
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| subClassOf |
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| No notes to display |