The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_0800 http://purl.obolibrary.org/obo/dinto_0800
Preferred Name	tissue-type plasminogen activator
Synonyms	t-plasminogen activator reteplase ec 3.4.21.68 alteplase tissue-type plasminogen activator precursor t- pa tpa
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	tissue-type plasminogen activator
label	tissue-type plasminogen activator
Definition	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration
type	http://www.w3.org/2002/07/owl#Class
Synonym	t-plasminogen activator reteplase ec 3.4.21.68 alteplase tissue-type plasminogen activator precursor t- pa tpa See more See less
OrganismClass	human
xref	UniProt ID:P00750 DrugBank:1792
definition source	DrugBank Database
prefixIRI	obo2:dinto_0800
related with	http://purl.obolibrary.org/obo/dinto_DB00013 http://purl.obolibrary.org/obo/dinto_DB04134 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/dinto_DB07684 http://purl.obolibrary.org/obo/CHEBI_63916
is pharmacological target of	http://purl.obolibrary.org/obo/dinto_DB00013 http://purl.obolibrary.org/obo/CHEBI_16586
is blocked by	http://purl.obolibrary.org/obo/CHEBI_16586
Gene	plat
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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