The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

alcohol dehydrogenase [nadp+]
Synonyms

aldehyde reductase

aldo-keto reductase family 1 member a1
ID

http://purl.obolibrary.org/obo/dinto_0461
binds

http://purl.obolibrary.org/obo/dinto_DB03461

http://purl.obolibrary.org/obo/dinto_DB02383

http://purl.obolibrary.org/obo/dinto_DB01907
Definition

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)
definition source

DrugBank Database
Gene

akr1a1
has substrate

http://purl.obolibrary.org/obo/dinto_DB00997

http://purl.obolibrary.org/obo/dinto_DB00157
is binded by

http://purl.obolibrary.org/obo/dinto_DB00997

http://purl.obolibrary.org/obo/dinto_DB00157
label

alcohol dehydrogenase [nadp+]
metabolizes

http://purl.obolibrary.org/obo/dinto_DB00997

http://purl.obolibrary.org/obo/dinto_DB00157
OrganismClass

human
prefixIRI

obo2:dinto_0461
prefLabel

alcohol dehydrogenase [nadp+]
related with

http://purl.obolibrary.org/obo/dinto_DB03461

http://purl.obolibrary.org/obo/dinto_DB02383

http://purl.obolibrary.org/obo/dinto_DB01907
Synonym

aldehyde reductase

aldo-keto reductase family 1 member a1
xref

UniProt ID:P14550

DrugBank:6861
subClassOf

http://purl.obolibrary.org/obo/dinto_000130

http://purl.obolibrary.org/obo/dinto_000128
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