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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_0461
http://purl.obolibrary.org/obo/dinto_0461
|
|---|---|
| Preferred Name | alcohol dehydrogenase [nadp+] |
| Synonyms |
aldehyde reductase
aldo-keto reductase family 1 member a1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | alcohol dehydrogenase [nadp+]
|
|---|---|
| label | alcohol dehydrogenase [nadp+]
|
| metabolizes | |
| Definition | Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)
|
| type | |
| Synonym |
aldehyde reductase
aldo-keto reductase family 1 member a1
|
| OrganismClass | human
|
| xref |
UniProt ID:P14550
DrugBank:6861
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_0461
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| related with | |
| Gene | akr1a1
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |