The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	mast/stem cell growth factor receptor
Synonyms	proto-oncogene tyrosine-protein kinase kit scfr mast/stem cell growth factor receptor precursor c-kit cd117 antigen ec 2.7.10.1
ID	http://purl.obolibrary.org/obo/dinto_0376
binds	http://purl.obolibrary.org/obo/dinto_DB03431 http://purl.obolibrary.org/obo/dinto_DB01962 http://purl.obolibrary.org/obo/CHEBI_45783
Definition	This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
definition source	DrugBank Database
Gene	kit
is binded by	http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/CHEBI_50924 http://purl.obolibrary.org/obo/CHEBI_68647 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/dinto_DB08901 http://purl.obolibrary.org/obo/CHEBI_52172 http://purl.obolibrary.org/obo/CHEBI_49375
is blocked by	http://purl.obolibrary.org/obo/CHEBI_52172 http://purl.obolibrary.org/obo/CHEBI_49375 http://purl.obolibrary.org/obo/CHEBI_50924 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_45783
is inhibited by	http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/dinto_DB08901 http://purl.obolibrary.org/obo/CHEBI_68647
is modulated by	http://purl.obolibrary.org/obo/CHEBI_52172 http://purl.obolibrary.org/obo/CHEBI_49375 http://purl.obolibrary.org/obo/CHEBI_50924 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_45783
is pharmacological target of	http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/CHEBI_50924 http://purl.obolibrary.org/obo/CHEBI_68647 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_45783
label	mast/stem cell growth factor receptor
OrganismClass	human
prefixIRI	obo2:dinto_0376
prefLabel	mast/stem cell growth factor receptor
related with	http://purl.obolibrary.org/obo/dinto_DB03431 http://purl.obolibrary.org/obo/dinto_DB01962 http://purl.obolibrary.org/obo/CHEBI_45783
Synonym	proto-oncogene tyrosine-protein kinase kit scfr mast/stem cell growth factor receptor precursor c-kit cd117 antigen ec 2.7.10.1
xref	UniProt ID:P10721 DrugBank:504
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/PR_000002065	CL	LOOM
http://purl.obolibrary.org/obo/PR_000002065	UBERON	LOOM
http://purl.obolibrary.org/obo/PR_000002065	OBA	LOOM
http://purl.uniprot.org/uniprot/P10721	FTC	LOOM
http://purl.obolibrary.org/obo/PR_000002065	PR	LOOM
http://purl.obolibrary.org/obo/PR_000002065	CLO	LOOM
http://purl.obolibrary.org/obo/PR_000002065	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000002065	OBI_BCGO	LOOM
http://purl.obolibrary.org/obo/PR_000002065	PCL	LOOM
http://purl.obolibrary.org/obo/PR_000002065	NIFDYS	LOOM
http://purl.obolibrary.org/obo/PR_000002065	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/PR_000002065	HHEAR	LOOM
http://purl.obolibrary.org/obo/PR_000002065	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000002065	UPHENO	LOOM
http://purl.obolibrary.org/obo/PR_000002065	NIFSTD	LOOM
http://purl.obolibrary.org/obo/PR_000002065	KTAO	LOOM
http://purl.obolibrary.org/obo/PR_000002065	MAXO	LOOM