loading...| Preferred Name |
tyrosine-protein kinase lyn |
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| Synonyms |
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| ID |
http://purl.obolibrary.org/obo/dinto_0350 |
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| binds | ||
| Definition |
Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress- activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1- dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents |
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| definition source |
DrugBank Database |
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| Gene |
lyn |
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| is binded by | ||
| is inhibited by | ||
| label |
tyrosine-protein kinase lyn |
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| OrganismClass |
human |
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| prefixIRI |
obo2:dinto_0350 |
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| prefLabel |
tyrosine-protein kinase lyn |
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| related with | ||
| xref |
UniProt ID:P07948 DrugBank:6824 |
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| subClassOf |