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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_0350
http://purl.obolibrary.org/obo/dinto_0350
|
|---|---|
| Preferred Name | tyrosine-protein kinase lyn |
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | tyrosine-protein kinase lyn
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|---|---|
| label | tyrosine-protein kinase lyn
|
| Definition | Down regulates expression of stem cell growth factor receptor (KIT). Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation (By similarity). Acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. Acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress- activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. Induces SAPK by a MKK7- and MEKK1- dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents
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| type | |
| is inhibited by | |
| OrganismClass | human
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| xref |
UniProt ID:P07948
DrugBank:6824
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_0350
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| related with | |
| Gene | lyn
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| subClassOf |
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| No notes to display |