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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_0195
http://purl.obolibrary.org/obo/dinto_0195
|
|---|---|
| Preferred Name | sialic acid-binding ig-like lectin 7 |
| Synonyms |
sialic acid-binding ig-like lectin 7 precursor
qa79 membrane protein
cd328 antigen
airm-1
siglec-7
cdw328
adhesion inhibitory receptor molecule 1
p75
d-siglec
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | sialic acid-binding ig-like lectin 7
|
|---|---|
| label | sialic acid-binding ig-like lectin 7
|
| Definition | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3 and alpha2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)
|
| type | |
| Synonym |
sialic acid-binding ig-like lectin 7 precursor
qa79 membrane protein
cd328 antigen
airm-1
siglec-7
cdw328
adhesion inhibitory receptor molecule 1
p75
d-siglec
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|
| OrganismClass | human
|
| xref |
DrugBank:2998
UniProt ID:Q9Y286
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_0195
|
| related with | |
| Gene | siglec7
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| subClassOf |
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