The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	protein-arginine deiminase type-4
Synonyms	protein-arginine deiminase type iv peptidylarginine deiminase iv ec 3.5.3.15 hl-60 pad
ID	http://purl.obolibrary.org/obo/dinto_0095
binds	http://purl.obolibrary.org/obo/CHEBI_16349 http://purl.obolibrary.org/obo/dinto_DB07449
Definition	Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1
definition source	DrugBank Database
Gene	padi4
label	protein-arginine deiminase type-4
OrganismClass	human
prefixIRI	obo2:dinto_0095
prefLabel	protein-arginine deiminase type-4
related with	http://purl.obolibrary.org/obo/CHEBI_16349 http://purl.obolibrary.org/obo/dinto_DB07449
Synonym	protein-arginine deiminase type iv peptidylarginine deiminase iv ec 3.5.3.15 hl-60 pad
xref	UniProt ID:Q9UM07 DrugBank:1814
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/NCIT_C102550	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D000080002	MESH	LOOM
http://id.nlm.nih.gov/mesh/D000080002	MDM	LOOM
http://purl.uniprot.org/uniprot/Q9UM07	FTC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102550	NCIT	LOOM
http://purl.obolibrary.org/obo/PR_000012222	EFO	LOOM
http://purl.obolibrary.org/obo/PR_000012222	PR	LOOM
http://purl.obolibrary.org/obo/PR_000012222	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000012222	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000012222	NIFSTD	LOOM
http://purl.obolibrary.org/obo/PR_000012222	OBA	LOOM