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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_8887
http://purl.obolibrary.org/obo/CHEBI_8887
|
|---|---|
| Preferred Name | rofecoxib |
| Synonyms |
rofecoxibum
rofecoxib
Ceoxx
4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
Rofecoxib
4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
C17H14O4S
4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Vioxx
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | rofecoxib
|
|---|---|
| label | rofecoxib
|
| DBSynonym |
mk 996
mk 966
|
| ATCCode | M01AH02
|
| Definition | A butenolide that is furan-2(5H)-one that is substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
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| has effect |
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| has pharmacological target | |
| induces | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N
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| is metabolised by | |
| Synonym |
rofecoxibum
rofecoxib
Ceoxx
4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
Rofecoxib
4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
C17H14O4S
4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Vioxx
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|
| xref |
KEGG DRUG:D00568
ChemSpider:4911
BindingDB:22369
Wikipedia:Rofecoxib
Drugs.com:http://www.drugs.com/mtm/rofecoxib.html
CiteXplore:16934051
RxList:http://www.rxlist.com/cgi/generic/rofecox.htm
CiteXplore:12069696
ChEBI:8887
PubChem Substance:46504787
Beilstein:8269007
PharmGKB:PA451268
CiteXplore:10859630
ChEMBL:121697
Drugs Product Database (DPD):2241109
Wikipedia:http://en.wikipedia.org/wiki/Rofecoxib
KEGG COMPOUND:C07590
CiteXplore:20162413
PubChem Compound:5090
DrugBank:DB00533
CiteXplore:11014111
Reaxys:8269007
CASRN:162011-90-7
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| CASRN | 162011-90-7
|
| prefixIRI | obo2:CHEBI_8887
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| related with | |
| SMILES |
CS(=O)(=O)C1=CC=C(C=C1)C1=C(C(=O)OC1)C1=CC=CC=C1
CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1
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| may interact with | |
| DBname | rofecoxib
|
| InChI | InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
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| DBBrand | vioxx
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |