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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_75991
http://purl.obolibrary.org/obo/CHEBI_75991
|
|---|---|
| Preferred Name | trametinib dimethyl sulfoxide |
| Synonyms |
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide--(methylsulfinyl)methane (1/1)
Mekinist
JTP 74057
GSK1120212B
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide
C26H23FIN5O4
GSK1120212
Trametinib DMSO
C26H23FIN5O4.C2H6OS
C28H29FIN5O5S
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | trametinib dimethyl sulfoxide
|
|---|---|
| label | trametinib dimethyl sulfoxide
|
| DBSynonym | gsk1120212
|
| ATCCode | L01XE25
|
| Definition | An addition compound obtained by combining equimolar amounts of trametinib and dimethyl sulfoxide. Used for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
|
| DBSalt | trametinib dimethyl sulfoxide
|
| has pharmacological target | |
| induces | |
| inhibits | |
| type | |
| has role | |
| InChIKey |
InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYNA-N
InChIKey=OQUFJVRYDFIQBW-UHFFFAOYSA-N
|
| AHFScode | 10:00
|
| Synonym | N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide--(methylsulfinyl)methane (1/1)
Mekinist
JTP 74057
GSK1120212B
N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide
C26H23FIN5O4
GSK1120212
Trametinib DMSO
C26H23FIN5O4.C2H6OS
C28H29FIN5O5S
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|
| xref |
Wikipedia:http://en.wikipedia.org/wiki/Trametinib
ChEMBL:1478011
KEGG DRUG:D10176
Wikipedia:Trametinib
CiteXplore:23432625
RxList:http://www.rxlist.com/mekinist-drug.htm
CiteXplore:22389471
National Drug Code Directory:0173-0848-13
CiteXplore:23848983
Reaxys:12497280
CiteXplore:22507781
Drugs.com:http://www.drugs.com/mekinist.html
CASRN:1187431-43-1
CiteXplore:22169769
CiteXplore:23248257
DrugBank:DB08911
CiteXplore:24030134
CiteXplore:24025354
CiteXplore:21245089
Patent:WO2005121142
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|
| CASRN | 871700-17-3
|
| prefixIRI | obo2:CHEBI_75991
|
| SMILES |
CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1
|
| DBname | trametinib
|
| InChI | InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3
InChI=1/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
|
| DBBrand | mekinist
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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