Link to this page
The Drug-Drug Interactions Ontology
| Preferred Name | nimodipine | |
| Synonyms |
nimodipinum C21H26N2O7 Nimodipine 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate nimodipine nimodipino Periplum Nimotop 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_7575 |
|
| activates | ||
| AHFScode |
24:28.08
|
|
| ATCCode |
C08CA06
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_1110 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_3324 http://purl.obolibrary.org/obo/dinto_1446 |
|
| blocks | ||
| CASRN |
66085-59-4
|
|
| DBBrand |
periplum nimotop nymalize
|
|
| DBname |
nimodipine
|
|
| DBSynonym |
nimodipino [inn-spanish] nimodipinum [inn-latin]
|
|
| Definition |
A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
|
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000599 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000882 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000779 |
|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_38215 |
|
| InChI |
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
|
|
| InChIKey |
InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N
|
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2957 http://purl.obolibrary.org/obo/dinto_2959 http://purl.obolibrary.org/obo/dinto_2975 http://purl.obolibrary.org/obo/dinto_2979 |
|
| is metabolised by | ||
| is substrate of | ||
| label |
nimodipine
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_39867 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_63628 |
|
| modulates | ||
| prefixIRI |
obo2:CHEBI_7575
|
|
| prefLabel |
nimodipine
|
|
| SMILES |
COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C
|
|
| Synonym |
nimodipinum C21H26N2O7 Nimodipine 3-(2-methoxyethyl) 5-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate nimodipine nimodipino Periplum Nimotop 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
|
|
| xref |
PubChem Substance:46508497 CASRN:66085-59-4 KEGG DRUG:D00438 ChEMBL:465248 Drugs.com:http://www.drugs.com/cdi/nimodipine.html BindingDB:50011690 ChEBI:7575 Reaxys:459792 DrugBank:DB00393 RxList:http://www.rxlist.com/cgi/generic2/nimodip.htm CiteXplore:21869451 KEGG COMPOUND:C07267 CiteXplore:12137606 Patent:US3799934 CiteXplore:22262041 NIST Chemistry WebBook:66085-59-4 Patent:DE2117571 IUPHAR:2523 National Drug Code Directory:57664-135-64 Wikipedia:http://en.wikipedia.org/wiki/Nimodipine CiteXplore:16180362 Drugs Product Database (DPD):2155923 CiteXplore:8519001 CiteXplore:22300914 PharmGKB:PA450633 PubChem Compound:4497 ChemSpider:4341 Wikipedia:Nimodipine CiteXplore:17110283 Guide To Pharmacology:2523
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |