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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_75045
http://purl.obolibrary.org/obo/CHEBI_75045
|
|---|---|
| Preferred Name | dabrafenib |
| Synonyms |
N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene-1-sulfonamide
N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
C23H20F3N5O2S2
dabrafenib
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | dabrafenib
|
|---|---|
| label | dabrafenib
|
| DBSynonym | gsk2118436
|
| ATCCode | L01XE23
|
| Definition | An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Dabrafenib mesylate is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. FDA approved on May 29, 2013.
|
| DBSalt | dabrafenib mesylate
|
| has pharmacological target | |
| induces | |
| inhibits |
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| type | |
| has role | |
| InChIKey |
InChIKey=BFSMGDJOXZAERB-UHFFFAOYNA-N
InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N
|
| is metabolised by | |
| AHFScode | 10:00
|
| Synonym | N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene-1-sulfonamide
N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
C23H20F3N5O2S2
dabrafenib
|
| xref |
CiteXplore:23714462
CiteXplore:23833299
CiteXplore:23537694
CiteXplore:23470635
CiteXplore:23249624
CiteXplore:23463215
CiteXplore:23237741
CiteXplore:23870055
Reaxys:19689971
Patent:WO2011047238
Wikipedia:http://en.wikipedia.org/wiki/Dabrafenib
CiteXplore:23290787
CiteXplore:23403819
CiteXplore:23844038
CiteXplore:23795808
RxList:http://www.rxlist.com/tafinlar-drug.htm
KEGG DRUG:D10064
CiteXplore:23552670
CiteXplore:23846776
National Drug Code Directory:0173-0847-08
CiteXplore:23317446
ChEMBL:1440894
Drugs.com:http://www.drugs.com/tafinlar.html
CiteXplore:22981500
CiteXplore:23656699
CiteXplore:23881668
CiteXplore:23617957
CiteXplore:23515890
CiteXplore:23621583
CiteXplore:23709751
CiteXplore:23276366
CiteXplore:23608920
CASRN:1195765-45-7
CiteXplore:23807941
Wikipedia:Dabrafenib
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| prefixIRI | obo2:CHEBI_75045
|
| is transported by | |
| SMILES |
CC(C)(C)C1=NC(=C(S1)C1=NC(N)=NC=C1)C1=C(F)C(NS(=O)(=O)C2=C(F)C=CC=C2F)=CC=C1
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1
|
| may interact with |
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|
| InChI | InChI=1/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
|
| DBBrand | tafinlar
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |