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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_746859
http://purl.obolibrary.org/obo/CHEBI_746859
|
|---|---|
| Preferred Name | travoprost |
| Synonyms |
travoprostum
C26H35F3O6
Travatan
travoprost
Travatan Z
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
Travoprost
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | travoprost
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|---|---|
| label | travoprost
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| ATCCode | S01EE04
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| Definition | The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol.
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| has effect |
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| has pharmacological target | |
| activates | |
| type | |
| has role | |
| InChIKey | InChIKey=MKPLKVHSHYCHOC-AHTXBMBWSA-N
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| AHFScode | 52:92.00
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| Synonym | travoprostum
C26H35F3O6
Travatan
travoprost
Travatan Z
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
Travoprost
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate
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| xref |
Reaxys:8739060
CASRN:157283-68-6
Wikipedia:Travoprost
CiteXplore:22167541
PubChem Compound:5282226
RxList:http://www.rxlist.com/cgi/generic2/travoprost.htm
PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tra1596.shtml
HMDB:HMDB14432
Drugs.com:http://www.drugs.com/cdi/travoprost-drops.html
DrugBank:DB00287
Wikipedia:http://en.wikipedia.org/wiki/Travoprost
PharmGKB:PA164781371
CiteXplore:22259229
PubChem Substance:46507637
ChEBI:746859
National Drug Code Directory:0065-0266-25
KEGG DRUG:D01964
ChemSpider:4445407
CiteXplore:22050687
Drugs Product Database (DPD):2244896
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| CASRN | 157283-68-6
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| prefixIRI | obo2:CHEBI_746859
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| SMILES |
CC(C)OC(=O)CCC\\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\\C=C\\[C@@H](O)COc1cccc(c1)C(F)(F)F
CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(=C1)C(F)(F)F
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| DBname | travoprost
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| InChI | InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
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| DBBrand |
travatan z
travatan
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| subClassOf |
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